Andreas Gießl, PD Dr. rer. nat. habil.

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Privatdozent; Scientific Staff

Email: Andreas.Giessl@fau.de
Phone: +49-(0)9131-85 28055
Fax:     +49-(0)9131-85 28060

Address

University of Erlangen-Nuremberg
Department of Biology
Animal Physiology
Staudtstrasse 5
91058 Erlangen, Germany

Building A2 - 1st Floor - Room 00.169

 

Research

The focus of my research is to investigate the function of vertebrate photoreceptor cells. My main interests are the basic cellular mechanisms by which cytoskeletal elements and protein complexes work together to regulate the distribution of molecules in the morphologically and functionally distinct compartments of photoreceptor cells.

Possible role of pericentrin in the ciliary transport in photoreceptor cells

Pericentrin – also known in human as kendrin – is one of the best-studied mammalian centrosomal proteins. Several spliced transcripts are encoded from one orthologous gene in mice and human, and pericentrin is characterized by coiled-coil domains throughout most of its structure and a PCM (peri-centrosomal-matrix) targeting motif called the PACT domain near its carboxyl terminus. We found with immunocytochemistry and high-resolution light microscopical analyses that pericentrin and several interacting partners, known from the centrosome, localize to the basal body and the centriole of the connecting cilium. Here they co-localize with the entire protein transport machinery from the inner to the outer segment of photoreceptor cells. Studying pericentrin function may help us to understand the regulation of protein transport in photoreceptor cells and provide new insights into human disorders related to defects in ciliary function.
My projects are embedded in international collaborations as well as in scientific networks at the University of Erlangen-Nuremberg.

 

Support

Deutsche Forschungsgemeinschaft DFG (Einzelförderung GI 770)
Dr. Hertha und Helmut Schmauser-Stiftung
Universitätsbund Erlangen-Nürnberg e.V.

 

Collaborations