Selected Publications Group Gießl


Böhm S, Riedmayr LM, Phuong Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E (2017) Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. Sci Rep 7(1):2321. doi: 10.1038/s41598-017-02514-5.

Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2016) Studying protein function and the role of altered protein expression by antibody interference and three-dimensional reconstructions. J Vis Exp 110, e53049, doi:10.3791/53049. [Article and Video].

Nguyen ON, Böhm S, Gießl A, Butz ES, Wolfrum U, Brandstätter JH, Wahl-Schott C, Biel M, Becirovic E (2016) Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Hum Mol Genet 25(12):2367-2377. doi: 10.1093/hmg/ddw103.

Gotthardt K, Lokaj M, Koerner C, Falk N, Gießl A, Wittinghofer A (2015) A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins. eLife 4. pii: e11859. doi: 10.7554/eLife.11859. [Article].

Falk N, Lösl M, Schröder N, Gießl A (2015) Specialized Cilia in Mammalian Sensory Systems. Cells 4(3), 500-519; Review; doi:10.3390/cells4030500. [Article].  [Special Issue Cilia and Flagella].

Zebrowski DC, Vergarajauregui S, Wu CC, Piatkowski T, Becker R, Leone M, Hirth S, Ricciardi F, Falk N, Gießl A, Just S, Braun T, Weidinger G, Engel FB (2015) Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. eLife 4. doi: 10.7554/eLife.05563. [Article].   Article in FAU News.

Wheway G, Schmidts M, Mans DA,..., Kessler K, Gießl A,...,Thiel CT, et al. (2015) An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol 17(8):1074-87. doi: 10.1038/ncb3201

Kessler K, Wunderlich I, Uebe S, Falk NS, Gießl A, Brandstätter JH, Popp B, Klinger P, Ekici AB, Sticht H, Dörr HG, Reis A, Roepman R, Seemanová E, Thiel CT (2015) DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects. Sci Rep 5:11649. doi: 10.1038/srep11649.

Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2015) Special characteristics of the transcription and splicing machinery in photoreceptor cells of the mammalian retina. Cell Tissue Res 362(2):281-94. doi: 10.1007/s00441-015-2204-x.

Zahnleiter D, Hauer NN, Kessler K, Uebe S, Sugano Y, Neuhauss SC, Gießl A, Ekici AB, Blessing H, Sticht H, Dörr HG, Reis A, Thiel CT (2015) MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation. Hum Mutat 36(1):87-97. doi: 10.1002/humu.22711.

Ramamurthy V, Jolicoeur C, Koutroumbas D, Mühlhans J, Zheng-Le Y, Hauswirth W, Gießl A, Cayouette M (2014) Numb regulates the polarized delivery of ion channels to mammalian light-sensing cilia. J Neurosci 34(42):13976-87.

Zahnleiter D, Hauer NH, Kessler K, Uebe S, Sugano Y, Neuhaus SCF, Gießl A, Ekici AB, Blessing H, Sticht H, Doerr GH, Reis A, Thiel CT (2014) MAP4 dependent regulation of microtubule formation affects centrosome, cilia and Golgi architecture as a central mechanism in growth regulation. Hum Mutat 36(1):87-97.

Jitschin R, Hofmann AD, Bruns H, Gießl A, Bricks J, Berger J, Saul D, Eckart MJ, Mackensen A, Mougiakakos D (2014) Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia. Blood doi: 10.1182/blood-2013-10-532200.

Derlig K, Ehrhardt T, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2014) Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons. Front Cell Neurosci Apr 08;8:99.

Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2013) Identification and characterisation of simiate, a novel protein linked to the fragile x syndrome. PLoS ONE 11;8(12):e83007.

Mühlhans J, Gießl A (2012) Pericentrin in health and disease: Exploring the patchwork of Pericentrin splice variants. Commun Integr Biol 5: 304-307.

Hümmler N, Schneider C, Gießl A, Bauer R, Walkinshaw G, Gassmann M, Rascher W, Trollmann R (2012) Acute hypoxia modifies regulation of neuroglobin in the neonatal mouse brain. Exp Neurol 236: 112-121.

Lin NY, Beyer C, Gießl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Kronke G, Spencer B, Distler O, Schett G, Distler JH (2012) Autophagy regulates TNFalpha-mediated joint destruction in experimental arthritis. Ann Rheum Dis Sep 12 (Epub ahead of print).

Beyer C, Stearns NA, Gießl A, Distler JH, Schett G, Pisetsky D (2012) The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death. Innate Immun Feb 16 (Epub ahead of print).

Mühlhans J, Brandstätter JH, Gießl A (2011) The Centrosomal Protein Pericentrin Identified at the Basal Body Complex of the Connecting Cilium in Mouse Photoreceptors. PLoS One 6(10):e26496

Thiel C, Kessler K, Gießl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stöss H, Beinder E, Jamra RA, Ekici AB, Schröder-Kreß N, Aigner T, Kirchner T, Reis A, Brandstätter JH, Rauch A (2011) NEK1 mutations cause Short-Rib Polydactyly Syndrome Type Majewski. Am J Hum Genet 88: 106-114.

Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Gießl A, Szurman P, Fischer MD, Wolfrum U, Wijnholds J, Remé CE, Humphries P, Seeliger MW (2010) Bone spicule formation in retinitis pigmentosa: Insights from a mouse model. Graefes Arch Clin Exp Ophthalmol 248: 1063-70.

Reidel B, Goldmann T, Gießl A, Wolfrum U (2008) The translocation of signaling molecules in dark adapting mammalian rod photoreceptor cells is dependent on the cytoskeleton. Cell Motil Cytoskeleton 65: 785-800.

Trojan P, Choe H-W, Krauß N, Gießl A, Pulvermüller A, Wolfrum U (2008) Centrin function in vertebrate photoreceptor cells. Prog Retin Eye Res 27: 237-59.

Trojan P, Rausch S, Gießl A, Klemm C, Krause E, Pulvermüller A, Wolfrum U (2008) Light-dependent CKII-mediated phosphorylation regulates centrin-G-protein complex formation in retinal photoreceptor cells. Biochimica et Biophysica Acta 1783: 1248-60.

Glube N, Gießl A, Wolfrum U, Langguth P (2007) Caki-1 Cells Represent an in vitro Model System for Studying the Human Proximal Tubule Epithelium. Nephron Exp Nephrol 107: e47-56.

Gießl A, Trojan P, Rausch S, Pulvermüller A, Wolfrum U (2006) Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium. Vision Res 46: 4502-4509.

Park JH, Pulvermüller A, Scheerer P, Rausch S, Gießl A, Hohne W, Wolfrum U, Hofmann KP, Ernst OP, Choe HW, Krauss N (2006) Insights into functional aspects of centrins from the structure of N-terminally extended mouse centrin 1. Vision Res 46: 4568-4574.

Park JH, Krauss N, Pulvermüller A, Scheerer P, Höhne W, Gießl A, Wolfrum U, Hofmann KP, Ernst OP, Choe H-W (2005) Crystallization and preliminary X-ray studies of mouse centrin 1. Acta Cryst F61: 510-513.

Shu X, Fry AM, Tulloch B, Manson FDC, Crabb JW, Khanna H, Faragher AJ, Lennon A, He S, Trojan P, Gießl A, Wolfrum U, Vervoort R, Swaroop A, Wright AF (2005) RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin. Hum Mol Genet 14: 1183-97.

Gießl A, Pulvermüller A, Trojan P, Park JH, Choe H-W, Ernst OP, Hofmann KP, Wolfrum U (2004) Differential expression and interaction with the visual G Protein transducin of centrin isoforms in mammalian photoreceptor cells. J Biol Chem 279: 51472-81.

Schmidt M*, Gießl A*, Laufs T, Hankeln T, Wolfrum U, Burmester T (2003) How does the eye breath? Evidence for neuroglobin-mediated oxygen supply of the vertebrate retina. J Biol Chem 278: 1932-5 (*authors contributed equally to this paper).

Schmitt T, Gießl A, Seitz A (2003) Did Polyommatus icarus (Lepidoptera: Lycaenidae) have distinct glacial refugia in southern Europe? Evidence from population genetics. Biological J of the Linnean Society 80: 529-538.

Wolfrum U, Gießl A, Pulvermüller A (2002) Centrins in vertebrate photoreceptor cells. Adv Exp Med Biol 514: 179-203.

Pulvermüller A, Gießl A, Heck M, Wottrich R, Schmitt A, Ernst OP, Choe H-W, Hofmann KP, Wolfrum U (2002) Calcium dependent assembly of centrin/G protein complex in photoreceptor cells. Mol Cell Biol 22: 2194-2203.

Schmitt T, Gießl A, Seitz A (2002) Postglacial colonisation of western Central Europe by Polyommatus coridon (Poda 1761) (Lepidoptera: Lycaenidae): evidence from population genetics. Heredity 88: 26-34.


Peer-reviewed book chapter


Gießl A, Trojan P, Pulvermüller A, Wolfrum U (2004) Centrins, potential regulators of transducin translocation in photoreceptor cells. Williams DS: Cell biology and related disease of the outer retina. World Scientific Publishing Company Pte. Ltd., Singapore 122-195.


Neuroforum chapter


Gießl A, Regus-Leidig H, Brandstätter JH (2010) Signal transduction and signal transmission: The two faces of a photoreceptor. e-Neuroforum Volume 1, Number 3, 60-69, DOI: 10.1007/s13295-010-0007-9.


Poster prices


Mühlhans J, Brandstätter JH, Gießl A (2010) Different Pericentrin-isoforms identified in mammalian photoreceptor cells. Pro Retina Research-Colloquium, Retinal Degeneration: 10 years into the new century, where do we go from here?, Potsdam.

Trojan P, Gießl A, Rausch S, Thissen M.C, Wonnenberg B, Klumpp S, Pulvermüller A, Wolfrum U (2007) Antagonistical regulatory mechanisms of centrin/G-protein assembly in the connecting cilium of photoreceptor cells. 7th Annual Meeting of the Interdisciplinary Science Network Molecular & Cellular Neurobiology, Mainz.

Gießl A, Schmidt M, Laufs T, Hankeln T, Wolfrum U, Burmester T (2003) How does the eye breathe? Neuroglobin-mediated oxygen supply in the mammalian retina. FASEB summer research conferences "The biology and chemistry of vision", p28, Tucson, Arizona.