Selected Publications Group Brandstätter and Regus-Leidig


Kurtenbach S, Gießl A, Strömberg S, Kremers J, Atorf J, Rasche S, Neuhaus EM, Hervé D, Brandstätter JH, Asan E, Hatt H, Kilimann MW (2017) The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia. Sci Rep [in press].

Schweitzer B, Singh J, Groc L, Fejtova A, Heine M, Frischknecht R (2017) Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors. Sci Rep [in press].

Löhner M, Babai N, Müller T, Gierke K, Altorf J, Joachimsthaler A, Peukert A, Martens H, Feigenspan A, Kremers J, Schoch S, Brandstätter JH, Regus-Leidig H (2017) Analysis of RIM expression and function at mouse photoreceptor ribbbon synapses. J Neurosci [in press].

Babai N, Sendelbeck A, Regus-Leidig H, Fuchs M, Mertins J, Reim K, Brose N, Feigenspan A, Brandstätter JH (2016) Functional roles of Complexin3 and Complexin4 at mouse photoreceptor ribbon synapses. J Neurosci 36(25):6651-67. doi: 10.1523/JNEUROSCI.4335-15.2016.

Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2016) Studying protein function and the role of altered protein expression by antibody interference and three-dimensional reconstructions. J Vis Exp 110, e53049, doi:10.3791/53049. [Article and Video].

Nguyen ON, Böhm S, Gießl A, Butz ES, Wolfrum U, Brandstätter JH, Wahl-Schott C, Biel M, Becirovic E (2016) Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Hum Mol Genet 25(12):2367-2377. doi: 10.1093/hmg/ddw103.

Regus-Leidig H, Fuchs M, Löhner M, Leist SR, Leal-Ortiz S, Chiodo VA, Hauswirth WW, Garner CC and Brandstätter JH (2014) In vivo knockdown of Piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses. Front Cell Neurosci 8:259 doi: 10.3389/fncel.2014.00259.

Derlig K, Ehrhardt T, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2014) Simiate is an Actin binding protein involved in filopodia dynamics and arborization of neurons. Front Cell Neurosci doi: 10.3389/fncel.2014.00099.

Fuchs M, Brandstätter JH, Regus-Leidig H (2014) Evidence for a Clathrin-independent mode of endocytosis at a continuously active sensory synapse. Front Cell Neurosci doi: 10.3389/fncel.2014.00060.

Regus-Leidig H, Atorf J, Feigenspan A, Kremers J, Maw MA, Brandstätter JH (2014) Photoreceptor degeneration in two mouse models for congenital stationary night blindness type 2. PLoS ONE 21;9(1):e86769.

Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2013) Identification and characterisation of simiate, a novel protein linked to the fragile x syndrome. PLoS ONE 11;8(12):e83007.

Regus-Leidig H, Ott C, Löhner M, Atorf J, Fuchs M, Sedmak T, Kremers J, Fejtová A, Gundelfinger ED, Brandstätter JH (2013) Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear. PLoS ONE 6;8(8):e70373.

Fuchs M*, Sendelbeck A*, Atorf J, Kremers J, Brandstätter JH (2013) Strain differences in illumination-dependent structural changes at mouse photoreceptor ribbon synapses. J Comp Neurol 521: 69-78 (*shared first authors).

Fuchs M*, Scholz M*, Sendelbeck A, Atorf J, Schlegel C, Enz R, Brandstätter JH (2012) Rod photoreceptor ribbon synapses in DBA/2J mice show progressive age-related structural changes. PLoS ONE 7:e44645 (*shared first authors).

tom Dieck S, Specht D, Strenzke N, Hida Y, Krisnamoorthy V, Schmidt K-F, Inoue E, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Hagiwara A, Brandstätter JH, Löwel S, Gollisch T, Ohtsuka T, Moser T (2012) Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing. J Neurosci 32: 12192-12203.

Landgraf I*, Mühlhans J*, Dedek K, Reim K, Brandstätter JH+, Ammermüller J+ (2012) The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina. Eur J Neurosci 36: 2470-2481 (*shared first authors; +shared corresponding authors).

Cooper B, Hemmerlein M, Ammermüller J, Imig C, Reim K, Lipstein N, Kalla S, Kawabe H, Brose N, Brandstätter JH+, Varoqueaux F+ (2012) Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses. J Neurosci 32: 8040-8052 (+shared corresponding authors).

Mühlhans J, Brandstätter JH, Gießl A (2011) The centrosomal protein Pericentrin identified at the basal body complex of the connecting cilium in mouse photoreceptors. PLoS ONE 6: e26496.

Hirano A, Brandstätter JH, Morgans CW, Brecha NC (2011) SNAP25 expression in mammalian retinal horizontal cells. J Comp Neurol 519: 972-988.

Regus-Leidig H, Specht D, tom Dieck S, Brandstätter JH (2010) Stability of active zone components at the photoreceptor ribbon complex. Mol Vis 16: 2690-2700.

Regus-Leidig H, tom Dieck S, Brandstätter JH (2010) Absence of functional active zone protein Bassoon affects assembly and transport of ribbon precursors during early steps of photoreceptor synaptogenesis. Eur J Cell Biol 89: 468-475.

Pasutto F, Matsumoto T, Mardin CY, Sticht H, Brandstätter JH, Michels-Rautenstrauss K, Weisschuh N, Gramer E, Ramdas WD, van Koolwijk LME, Klaver CCW, Vingerling JR, Weber BHF, Kruse FE, Rautenstrauss B, Barde YA, Reis A (2009) Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am J Hum Genet 85: 447-456.

Reim K, Regus-Leidig H, Ammermüller J, El-Kordi A, Radyushkin K, Ehrenreich H, Brandstätter JH*, Brose N* (2009) Aberrant function and structure of retinal ribbon synapses in the absence of Complexin 3 and 4. J Cell Sci 122: 1352-1361 (*shared corresponding authors).

Regus-Leidig H, tom Dieck S, Specht D, Meyer, L, Brandstätter JH (2009) Early steps in the assembly of photoreceptor ribbon synapses: The involvement of precursor spheres. J Comp Neurol 512: 814-824.

Specht D*, tom Dieck S*, Ammermüller J*, Regus-Leidig H, Gundelfinger ED, Brandstätter JH (2007) Structural and functional remodeling in the retina of a mouse with a photoreceptor synaptopathy: Plasticity in the rod and degeneration in the cone system. Eur J Neurosci 26: 2506-2515 (*authors contributed equally to this paper).

Reim K*, Wegmeyer H*, Brandstätter JH*, Xue M*, Rosenmund C, Dresbach T, Hofmann K, Brose N (2005) Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol 169: 669-680 (*authors contributed equally to this paper).

tom Dieck S, Altrock WD, Kessels M, Qualmann B, Regus H, Brauner D, Fejtová A, Bracko O, Gundelfinger ED, Brandstätter JH (2005) Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. J Cell Biol 168: 825-836.

Dick O, tom Dieck S, Altrock WD, Ammermüller J, Weiler R, Garner CC, Gundelfinger ED, Brandstätter JH (2003) The presynaptic active zone protein Bassoon is essential for photoreceptor ribbon synapse formation in the retina. Neuron 37: 775-786.

Altrock WD, tom Dieck S, Sokolov M, Meyer AC, Sigler A, Brakebusch C, Fässler R, Richter K, Boeckers TM, Potschka H, Brandt C, Löscher W, Grimberg D, Dresbach T, Hempelmann A, Hassan H, Balschun D, Frey JU, Brandstätter JH, Garner CC, Rosenmund C, Gundelfinger ED (2003) Functional inactivation of a fraction of excitatory glutamatergic synapses in mice deficient for the active zone protein Bassoon. Neuron 37: 787-800.

Hack I, Peichl L, Brandstätter JH (1999) An alternative pathway for rod signals in the rodent retina: rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors. Proc Natl Acad Sci, USA 96: 14130-14135.

Koulen P, Kuhn R, Wässle H, Brandstätter JH (1999) Modulation of the intracellular calcium concentration in photoreceptor terminals by a presynaptic metabotropic glutamate receptor. Proc Natl Acad Sci, USA 96: 9909-9914.


Selected Reviews


Regus-Leidig H, Brandstätter JH (2011) Structure and function of a complex sensory synapse. Acta Physiol (Oxf.) 204: 479-486, DOI: 10.1111/j.1748-1716.2011.02355.x [Epub 2011 Oct 17].

Gießl A, Regus-Leidig H, Brandstätter JH (2010) Signal transduction and signal transmission: The two faces of a photoreceptor. e-Neuroforum Volume 1, Number 3, 60-69, DOI: 10.1007/s13295-010-0007-9.

Brandstätter JH, tom Dieck S (2006) Ribbon synapses of the retina. Special Issue „The Synapse - recent advances“. Cell Tissue Res 326: 339-346.

Brandstätter JH (2002) Glutamate receptors in the retina: The molecular substrate for visual signal processing. Curr Eye Res 25: 327-331.

Brandstätter JH, Hack I (2001) Localization of glutamate receptors at a complex synapse: The mammalian photoreceptor synapse. Cell Tissue Res 303: 1-14.

Brandstätter JH, Koulen P, Wässle H (1998) Diversity of glutamate receptors in the mammalian retina. Vis Research 38: 1385-1397.